Paeonia lactiflora Pall. has been used in the treatment of rheumatoid arthritis, systemic
lupus erythematosus, hepatitis, dysmenorrhea, muscle cramping and
spasms, and fever for more than 1200 years.
A water/ethanol extract of the root is now known as total
glucosides of peony (TGP), which contains more than 15 components.
Paeoniflorin is the most abundant ingredient and accounts for the
pharmacological effects observed with TGP in both vitro and in vivo
|Product name||Paeoniflorin powder paeonia lactiflora extract|
|Appearance||Brown yellow powder|
|Product packaging||Packaging can be customized according to customer requirements.|
|Shelf life||24 Months Properly Storage|
1. The effect on the central nervous system Paeoniflorin has
significant analgesic, sedative and anticonvulsant effects. Peony
extract can antagonize the convulsions caused by strychnine.
Intraperitoneal injection of mice has a significant analgesic
effect, and the analgesic effect may not be related to morphine
receptors. It can prolong the sleep time of mice with globodone
barbital sodium, and has an antagonistic effect on convulsions
caused by pentamethylenetetrazole.
2. Effects on the heart and cerebrovascular system. Vascular
expansion: Paeoniflorin can dilate the coronary arteries, increase
coronary flow, combat acute myocardial ischemia, and lower blood
pressure. Protecting cerebral ischemia: the effect of paeoniflorin
on the blood-brain barrier and neuropathological changes of
cerebral ischemia and cerebral blood flow during reperfusion after
cerebral ischemia. It was found that paeoniflorin has protective
effects on brain edema, blood-brain barrier, and local blood flow
in the brain after cerebral ischemia. Application of paeoniflorin
to animals with focal cerebral ischemia can significantly reduce
the degree of cerebral edema, reduce the scope of cerebral
infarction, improve neurobehavioral symptoms, blood-brain barrier
permeability, and increase local blood flow in the brain. Shows a
significant protective effect on focal cerebral ischemia injury,
its protective mechanism may be related to the following factors;
inhibition of intracellular calcium ion overload, anti-free
radicals, ischemia, hypoxia-induced cerebral vasomotor dysfunction
It has a good improving effect, has a protective effect on the
blood-brain barrier during reperfusion after cerebral ischemia, and
can promote the recovery of cerebral blood flow in the early stage
of reperfusion. Anti-thrombosis effect: Experiments show that
compared with the control group, the platelet aggregation time of
the paeoniflorin model group is reduced by about 1/2, indicating
that the platelet aggregation of the paeoniflorin in the high-fat
and high-cholesterol animal is enhanced, and the platelet of the
model administration group is Aggregation, platelet thrombosis and
fibrin formation time were significantly longer than those in the
model group, and were close to the control group. It is suggested
that paeoniflorin can improve the anti-thrombosis effect caused by
high fat and high cholesterol. Anti-platelet aggregation effect:
Platelet aggregation is one of the important "culprits" causing
various types of cardiovascular and cerebrovascular diseases.
Paeoniflorin has varying degrees of inhibition on platelet
aggregation induced by ADP and collagen. Anti-hyperlipidemia
effect: Scholars from Ulsan University in South Korea found that
for experimental hyperlipidemia rat models, paeoniflorin has the
effect of lowering its cholesterol level. Compared with the control
group, when the doses of the test group were 200 and 400 mg/kg,
orally, once a day for 4 weeks, paeoniflorin showed a significant
reduction in total cholesterol, low-density lipoprotein and
triglyceride levels. effect. Reversing the effect of hypotension:
Through intravenous injection of paeoniflorin, Taiwanese medical
workers discovered that paeoniflorin can reverse the hypotension
induced by ethidine by activating the adenosine A1 receptor in the
brain of West rats. After pretreatment with the adenosine A1
receptor antagonist 8-cyclopenta-1,3-dipropylxanthine, paeoniflorin
has a dose-dependent inhibitory effect. This effect of paeoniflorin
will not be changed by 8-thiophenylphylline, which is a strong
polar adenosine A1 receptor antagonist that cannot enter the
central nervous system.
3. Antispasmodic effect Paeoniflorin can relax smooth muscle cells.
Ca2+ reduction plays an important role in the smooth muscle cell
relaxation of paeoniflorin. Paeoniflorin may relax smooth muscle
cells by regulating cell membrane Ca2+/Na+ exchange. In the smooth
muscle cells of the gastrointestinal tract, the membrane potential
determines the contraction and relaxation of the gastrointestinal
tract by affecting the excitability of the smooth muscle cells. The
pharmacological effects of paeoniflorin are mainly to inhibit
parasympathetic nerve excitement, reduce smooth muscle tension and
inhibit its movement. Some experiments have confirmed that
paeoniflorin has an inhibitory effect on the tonic contraction of
the smooth muscle of the epididymis and prostate of the rat vas
deferens; it has an inhibitory effect on the isolated intestinal
tube and in vivo gastric movement of guinea pigs and rats, and the
smooth muscle of the uterus of rats, and can antagonize them. The
contraction of the uterus caused by oxytocin. At the same time,
some scholars have used white peony formula to treat irritable
bowel syndrome and recurrent colic after cholelithiasis, and they
have achieved certain effects. By relaxing the sphincter,
paeoniflorin is beneficial to the excretion of bile and pancreatic
juice during acute pancreatitis, thereby reducing the activation of
pancreatic enzymes, reducing pancreatic acinar damage, and
ultimately reducing the severity of acute pancreatitis.
4. Antipyretic effect Paeoniflorin has a lowering effect on the
body temperature of normal mice and a heat transfer effect on mice
with artificial fever.
5. Anti-inflammatory, anti-ulcer and anti-allergic effects
Paeoniflorin (50mg/kg, ig) has an inhibitory effect on rat ankle
swelling caused by carrageenan and dextrose, and has an adjuvant
arthritis effect in rats. It has a preventive effect, has a
preventive effect on stress ulcers in rats and inhibits gastric
juice secretion. White peony decoction has inhibitory effect on
certain pathogenic bacteria and fungi.
6. Hypoglycemic effect: Intravenous injection of paeoniflorin can
significantly reduce the blood sugar of diabetic mice induced by
streptozotocin, and the sugar content in plasma also gradually
decreases with the extension of the medication time. It has the
strongest effect at 25min after medication. Paeoniflorin reduces
the level of sugar content in plasma, and its effect is related to
the amount (1-10mg/kg body weight). Experiments show that the
mechanism of paeoniflorin in lowering blood sugar has nothing to do
Seven, immunomodulatory effect Paeoniflorin has a certain
immunomodulatory function. Adjuvant arthritis was induced with an
appropriate amount of concanavalin. Paeoniflorin acts on spleen
cell suspension and peritoneal macrophages in vitro, and found that
IL-2 produced by rat spleen lymphocytes and rat peritoneal
macrophages produced IL-1. Both have a strengthening effect, and
the dose-effect curve is like a bell jar. Moreover, it can induce
the proliferation of splenic lymphocytes, and can restore a large
number of low splenic lymphocytes proliferation of AA rats and
approach the normal level, indicating that paeoniflorin has a
concentration and function-dependent two-way immunomodulatory
effect. Clinical pharmacological studies have shown that the
product can improve the condition of patients with rheumatoid
arthritis, reduce the symptoms and signs of patients, and can
regulate the immune function of patients. Paeoniflorin has similar
efficacy to methotrexate in the treatment of rheumatoid arthritis,
but its side effects are significantly less and lighter than
methotrexate. As a class II western medicine, it has been approved
as a new drug for the clinical treatment of rheumatoid arthritis.
Its other clinical applications are under study.
8. Anti-tumor effect Paeoniflorin has a certain inhibitory effect
on tumor cells. Paeoniflorin can inhibit the activity of ATPase on
tumor cell membrane and increase the activity of adenylate and
cyclase (AC). The drug inhibits the formation of tumor cells and is
closely related to the inhibition of Na, K-ATPase on the membrane
and the activation of AC. The effects of paeoniflorin on the
proliferation of human liver cancer cell lines Bel-7402 and HepG2
were observed, and the proliferation results of tumor cells were
observed by three measures (negative drug-free control, positive
adriamycin control and paeoniflorin). Among them, paeoniflorin
(2mg/ml) , 1mg/ml, 0.5mg/ml) have a significant inhibitory effect
on the proliferation of Bel-7402 and HepG2 cells, and their maximum
inhibition rates are 33.78% and 31.45%, respectively. The
proliferation inhibitory effect increases with the increase of the
drug concentration, showing a significant dose-effect relationship.
The results of the study show that the effective drug
concentrations of 2mg/ml, 1mg/ml and 0.5mg/ml paeoniflorin suggest
that paeoniflorin can inhibit the proliferation of human liver
cancer cells to a certain extent to delay the progress of liver
cancer. It can induce HepG2 apoptosis, up-regulate the expression
of apoptosis-related genes P53 and bax, and down-regulate the
expression of anti-apoptotic gene bcl-2. Anti-tumor experiments
confirmed that the inhibition rate of paeoniflorin on S-180 solid
tumors was 36%-44%%. Compared with the control group, paeoniflorin
was significantly different. Cyclophosphamide for the treatment of
lung cancer has no significant effect on the primary tumor,
metastasis rate and number of lung metastases of Lewis lung cancer,
but the combination of paeoniflorin and red peony A can
significantly reduce the number of lung metastases.
9. Protective effect on the liver Paeoniflorin can stimulate the
rat to produce plasma fibronectin, promote the increase of its
blood level, and promote the function of the reticuloendothelial
system. Prophylactic administration of paeoniflorin for 7
consecutive days can significantly counteract the increase of serum
alanine aminotransferase, the decrease of serum albumin and the
decrease of liver glycogen content after liver injury in mice
caused by D-galactosamine or carbon tetrachloride, and make the
form The degeneration and necrosis of liver cells have been
significantly improved and restored. Paeoniflorin also has an
inhibitory effect on the elevation of serum transaminase induced by
10. Prevention and treatment of senile dementia.
11. Resistance to hypoxia, etc.
12. The role of diuresis.
1. It can relax muscle and cleanse the blood;
2. It can help regulate the female hormonal cycle;
3. It can tonify and purify the blood;
4. It can be used as a pain reducing agent and as an emotional stabilizer by
5. It can relieve cramps and spasms anywhere in the body;
6. It has an antiaging effect without effecting hormones for men.
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Why choose us
Hunan Warrant Pharmaceutical Co., Ltd founded in 2001 with registered capital of 70.3 millions rmb, and
has three manufacturing factories, three R&D centers and a
trading company. All of our factories are GMP certified. We are a
good supplier of professional herb extracts, especially those with
high purity and standardized production process. There are two
workshops of pre-processing and extracts of traditional Chinese
2.High quality with cometitive Manufacturer Direct price.
3.Free Sample Supply.
4.Small order is acceptable.
5.High purity and large production capacity.
Q1: How to confirm the Product Quality before placing orders?
A: By sending you our available samples. Or if you have special
requirement on the goods, we can prepare samples according to your
requirement and send to you for your confirmation.
Q2: Can you supply free samples?
A: Of course yes, we can provide some free sample, but the shipping
cost should be on the customers’ account. You can either pay us the
shipping cost or arrange a courier to collect the samples.
Q3: What’s the MOQ?
A: The MOQ for most of our products is 1kg.
Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price.
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